The seco-iridoid pathway from Catharanthus roseus

  title={The seco-iridoid pathway from Catharanthus roseus},
  author={Karel Miettinen and Lemeng Dong and Nicolas Navrot and T. Schneider and V. Burlat and Jacob Pollier and L. Woittiez and Sander van der Krol and Rapha{\"e}l Lugan and Tina Ilc and R. Verpoorte and K. Oksman-Caldentey and E. Martinoia and H. Bouwmeester and A. Goossens and J. Memelink and D. Werck-Reichhart},
  journal={Nature Communications},
  • Karel Miettinen, Lemeng Dong, +14 authors D. Werck-Reichhart
  • Published 2014
  • Biology, Medicine
  • Nature Communications
  • The (seco)iridoids and their derivatives, the monoterpenoid indole alkaloids (MIAs), form two large families of plant-derived bioactive compounds with a wide spectrum of high-value pharmacological and insect-repellent activities. Vinblastine and vincristine, MIAs used as anticancer drugs, are produced by Catharanthus roseus in extremely low levels, leading to high market prices and poor availability. Their biotechnological production is hampered by the fragmentary knowledge of their… CONTINUE READING
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    Present status of Catharanthus roseus monoterpenoid indole alkaloids engineering in homo- and hetero-logous systems
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    Spatial organization of the vindoline biosynthetic pathway in Catharanthus roseus.
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    CathaCyc, a metabolic pathway database built from Catharanthus roseus RNA-Seq data.
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