The seco-iridoid pathway from Catharanthus roseus

@inproceedings{Miettinen2014TheSP,
  title={The seco-iridoid pathway from Catharanthus roseus},
  author={Karel Miettinen and Lemeng Dong and Nicolas Navrot and Thomas Schneider and Vincent Burlat and Jacob Pollier and Lotte S. Woittiez and Sander van der Krol and Rapha{\"e}l Lugan and Tina Ilc and Robert Verpoorte and Kirsi-Marja Oksman-Caldentey and Enrico Martinoia and Harro Bouwmeester and Alain Goossens and Johan Memelink and Daniele Werck-reichhart},
  booktitle={Nature communications},
  year={2014}
}
The (seco)iridoids and their derivatives, the monoterpenoid indole alkaloids (MIAs), form two large families of plant-derived bioactive compounds with a wide spectrum of high-value pharmacological and insect-repellent activities. Vinblastine and vincristine, MIAs used as anticancer drugs, are produced by Catharanthus roseus in extremely low levels, leading to high market prices and poor availability. Their biotechnological production is hampered by the fragmentary knowledge of their… CONTINUE READING
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