The search for trans-acting factors controlling messenger RNA decay.

@article{Wilson1999TheSF,
  title={The search for trans-acting factors controlling messenger RNA decay.},
  author={Gerald M. Wilson and Gary Brewer},
  journal={Progress in nucleic acid research and molecular biology},
  year={1999},
  volume={62},
  pages={257-91}
}
Control of mRNA turnover is an integral component of regulated gene expression. Individual mRNAs display a wide range of stabilities, which in many cases have been linked to discrete sequence elements. The most extensively characterized determinants of rapid constitutive mRNA turnover in mammalian systems are A + U-rich elements (AREs), first identified in… CONTINUE READING