The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets.

@article{Hohlfeld2016TheSF,
  title={The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets.},
  author={Reinhard Hohlfeld and Klaus Dornmair and Edgar Meinl and Hartmut Wekerle},
  journal={The Lancet. Neurology},
  year={2016},
  volume={15 2},
  pages={
          198-209
        }
}
Identification of the target antigens of pathogenic antibodies and T cells is of fundamental importance for understanding the pathogenesis of multiple sclerosis, and for the development of personalised treatments for the disease. Myelin-specific CD4+ T cells emerged long ago as a key player in animal models of multiple sclerosis. Taking a forward-translational approach, autoreactive CD4+ T cells have been studied extensively in patients with multiple sclerosis, and there is evidence, but as yet… CONTINUE READING
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