The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets

@article{Hohlfeld2016TheSF,
  title={The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets},
  author={R. Hohlfeld and K. Dornmair and E. Meinl and H. Wekerle},
  journal={The Lancet Neurology},
  year={2016},
  volume={15},
  pages={198-209}
}
  • R. Hohlfeld, K. Dornmair, +1 author H. Wekerle
  • Published 2016
  • Medicine
  • The Lancet Neurology
  • Identification of the target antigens of pathogenic antibodies and T cells is of fundamental importance for understanding the pathogenesis of multiple sclerosis, and for the development of personalised treatments for the disease. Myelin-specific CD4+ T cells emerged long ago as a key player in animal models of multiple sclerosis. Taking a forward-translational approach, autoreactive CD4+ T cells have been studied extensively in patients with multiple sclerosis, and there is evidence, but as yet… CONTINUE READING
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    References

    SHOWING 1-10 OF 112 REFERENCES
    Antigen-specific tolerization approaches in multiple sclerosis
    • 31
    • PDF
    Multiple sclerosis: a complicated picture of autoimmunity
    • 900
    Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: From pipe dreams to (therapeutic) pipelines
    • R. Hohlfeld, H. Wekerle
    • Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2004
    • 239
    • PDF
    High Incidence of Spontaneous Disease in an HLA-DR15 and TCR Transgenic Multiple Sclerosis Model1
    • 72
    • PDF
    Immunology of multiple sclerosis.
    • 370
    • PDF
    The re-emergence of antigen-specific tolerance as a potential therapy for MS
    • 18
    T cell vaccination in multiple sclerosis: a preliminary report.
    • 56