The search for the palmitoylethanolamide receptor.

  title={The search for the palmitoylethanolamide receptor.},
  author={Jesse Loverme and Giovanna La Rana and Roberto Russo and Antonio Calignano and Daniele Piomelli},
  journal={Life sciences},
  volume={77 14},
Palmitoylethanolamide (PEA), the naturally occurring amide of ethanolamine and palmitic acid, is an endogenous lipid that modulates pain and inflammation. Although the anti-inflammatory effects of PEA were first characterized nearly 50 years ago, the identity of the receptor mediating these actions has long remained elusive. We recently identified the ligand-activated transcription factor, peroxisome proliferator-activated receptor-alpha (PPAR-alpha), as the receptor mediating the anti… CONTINUE READING