The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals.

@article{Murabito2012TheSF,
  title={The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals.},
  author={Joanne M. Murabito and Rong Yuan and Kathryn L. Lunetta},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2012},
  volume={67 5},
  pages={470-9}
}
Genetic factors clearly contribute to exceptional longevity and healthy aging in humans, yet the identification of the underlying genes remains a challenge. Longevity is a complex phenotype with modest heritability. Age-related phenotypes with higher heritability may have greater success in gene discovery. Candidate gene and genome-wide association studies (GWAS) for longevity have had only limited success to date. The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium… CONTINUE READING
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