The search for hemizygosity at 22qll in patients with isolated cleft palate.

@article{Mingarelli1996TheSF,
  title={The search for hemizygosity at 22qll in patients with isolated cleft palate.},
  author={Rita Mingarelli and M. C. Digilio and Aldo Mari and Francesca Amati and L. Standoli and Aldo Giannotti and Giuseppe Novelli and Bruno Dallapiccola},
  journal={Journal of craniofacial genetics and developmental biology},
  year={1996},
  volume={16 2},
  pages={118-21}
}
The striking association between oral clefting and the velocardio-facial syndrome (VCFS), a common disorder pathogenetically related to 22q11 deficiency, has prompted the search for this deletion in a group of patients with isolated cleft palate. (CP). Thirty-three patients with posterior CP and 5 with complete CP were included in this study, together with 12 patients with a clinical diagnosis of VCFS. Standard and high resolution chromosome analysis was performed, providing normal results… CONTINUE READING