The search for a marsupial XIC reveals a break with vertebrate synteny

  title={The search for a marsupial XIC reveals a break with vertebrate synteny},
  author={Lance S Davidow and Matthew G. Breen and Shannon E. Duke and Paul B. Samollow and John R. McCarrey and Jeannie T Lee},
  journal={Chromosome Research},
X-chromosome inactivation (XCI) evolved in mammals to deal with X-chromosome dosage imbalance between the XX female and the XY male. In eutherian mammals, random XCI of the soma requires a master regulatory locus known as the ‘X-inactivation center’(XIC/Xic), wherein lies the noncoding XIST/Xist silencer RNA and its regulatory antisense Tsix gene. By contrast, marsupial XCI is imprinted to occur on the paternal X chromosome. To determine whether marsupials and eutherians share the XIC-driven… CONTINUE READING
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