The search for a digitalis substitute II milrinone (Win 47203). Its action on the heart-lung preparation of the dog.

@article{Pasteln1983TheSF,
  title={The search for a digitalis substitute II milrinone (Win 47203). Its action on the heart-lung preparation of the dog.},
  author={Gustavo Pastel{\'i}n and Rafael M{\'e}ndez and Emilio Kabela and Alfred Farah},
  journal={Life sciences},
  year={1983},
  volume={33 18},
  pages={
          1787-96
        }
}
Milrinone (Win 47203) is a dipyridine related to amrinone, which is about 20-50 times as effective as amrinone when assayed on cardiac contractility. In dog heart-lung preparations, milrinone in a concentration of 0.25-0.5 microM produced a near maximal positive inotropic effect on a variety of acute heart failures. This dosage produced a minimal increase… CONTINUE READING