The scientific and clinical basis for the treatment of Parkinson disease (2009)

@article{Olanow2009TheSA,
  title={The scientific and clinical basis for the treatment of Parkinson disease (2009)},
  author={C. Warren Olanow and Matthew B. Stern and Kapil Sethi},
  journal={Neurology},
  year={2009},
  volume={72},
  pages={S1 - S136}
}
Parkinson disease (PD) is an age-related neurodegenerative disorder that affects as many as 1–2% of persons aged 60 years and older. With the aging of the population, the frequency of PD is expected to increase dramatically in the coming decades. Current therapy is largely based on a dopamine replacement strategy, primarily using the dopamine precursor levodopa. However, chronic treatment is associated with the development of motor complications, and the disease is inexorably progressive… 

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