The schistosome enzyme that activates oxamniquine has the characteristics of a sulfotransferase.

  title={The schistosome enzyme that activates oxamniquine has the characteristics of a sulfotransferase.},
  author={L. Pica-Mattoccia and Daniele Carlini and A. Guidi and Velasco Cimica and F. Vigorosi and D. Cioli},
  journal={Memorias do Instituto Oswaldo Cruz},
  volume={101 Suppl 1},
  • L. Pica-Mattoccia, Daniele Carlini, +3 authors D. Cioli
  • Published 2006
  • Biology, Medicine
  • Memorias do Instituto Oswaldo Cruz
  • Available evidence suggests that the antischistosomal drug oxamniquine is converted to a reactive ester by a schistosome enzyme that is missing in drug-resistant parasites. This study presents data supporting the idea that the active ester is a sulfate and the activating enzyme is a sulfotransferase. Evidence comes from the fact that the parasite extract loses its activating capability upon dialysis, implying the requirement of some dialyzable cofactor. The addition of the sulfate donor 3… CONTINUE READING

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