The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases.

@article{Liu2002TheSM,
  title={The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases.},
  author={Hudan Liu and Nancy Day Rodgers and Xinfu Jiao and Megerditch Kiledjian},
  journal={The EMBO journal},
  year={2002},
  volume={21 17},
  pages={
          4699-708
        }
}
We recently demonstrated that the major decapping activity in mammalian cells involves DcpS, a scavenger pyrophosphatase that hydrolyzes the residual cap structure following 3' to 5' decay of an mRNA. The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. We purified DcpS from mammalian cells and identified the cDNA encoding a novel 40 kDa protein possessing DcpS… CONTINUE READING
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