The sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA) is the third element in capacitative calcium entry.

@article{Manjarrs2010TheSR,
  title={The sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA) is the third element in capacitative calcium entry.},
  author={Isabel Mart{\'i}n Manjarr{\'e}s and Arancha Rodr{\'i}guez-Garc{\'i}a and M. T. Alonso and Javier Garc{\'i}a-Sancho},
  journal={Cell calcium},
  year={2010},
  volume={47 5},
  pages={
          412-8
        }
}
STIM1 and Orai1 are the main players in capacitative calcium entry (CCE). STIM1 senses [Ca(2+)] inside the endoplasmic reticulum (ER) and, when it decreases, opens Orai1, a store-operated calcium channel (SOC) in the plasma membrane that promotes Ca(2+) entry and increases cytosolic Ca(2+). The final destination of the entering Ca(2+) is the ER, which refills very efficiently (capacitatively) with it. We propose here that SERCA is the third element of CCE, to which is tightly coupled to favour… CONTINUE READING
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SERCA and CCE

  • M. M. Wu, J. Buchanan, R. M. Luik, R. S. Lewis
  • J. Cell Biol. 174,
  • 2006
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