The sarcin/ricin loop, a modular RNA.

  title={The sarcin/ricin loop, a modular RNA.},
  author={Alexander A. Szewczak and Peter B Moore},
  journal={Journal of molecular biology},
  volume={247 1},
The conformation of a 29 base oligonucleotide called E73 has been determined in solution by NMR. E73 includes a 23 nucleotide sequence that is identical with that of a the alpha-sarcin and ricin-sensitive loop (SRL) from rat 28 S rRNA, and like the SRL in intact ribosomes, E73 is a substrate for both toxins. The SRL includes a long, conserved sequence found in the RNA of all large ribosomal subunits, which plays a critical role in the factor-dependent steps of protein synthesis. The… CONTINUE READING


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