746 Citations
Safety of statins: an update
- MedicineTherapeutic advances in drug safety
- 2012
Statins are widely used and have been proven to be effective in the prevention of atherosclerotic vascular disease events, primarily by reducing plasma low-density lipoprotein cholesterol…
Non-cardiovascular effects associated with statins
- Medicine, BiologyBMJ : British Medical Journal
- 2014
Current systematic reviews and clinical practice guidelines indicate that the cardiovascular benefits of statins generally outweigh non-cardiovascular harms in patients above a certain threshold of cardiovascular risk.
Dyslipidemia: Treatment in Statin – Intolerant Patients
- Biology, Medicine
- 2013
The first step in handling intolerant patients is to rule out any secondary causes of myopathy or liver toxicity, and the use of non-lipid lowering drugs, such as ezetimibe, bile acids sequestrants and fibrates, alone or in combination are considered.
Statins in the treatment of dyslipidemia in the presence of elevated liver aminotransferase levels: a therapeutic dilemma.
- Medicine, BiologyMayo Clinic proceedings
- 2010
This review supports the use of statin treatment in patients with high cardiovascular risk whose elevated aminotransferase levels have no clinical relevance or are attributable to known stable chronic liver conditions.
Statin safety and chronic liver disease
- MedicineInternational journal of clinical practice
- 2008
There are an increasing number of referrals to both lipid and liver clinics regarding the use of statins in the setting of chronic liver disease and also the cause of elevated liver enzymes in patients who are on statins, and current prescribing strategies in these two patient populations are clarified.
Safety of statins
- Biology, MedicineIndian journal of endocrinology and metabolism
- 2013
Understanding of the mechanisms behind adverse effects of statins including an insight into the pharmacokinetic properties have minimised fear of statin use among clinicians and awareness of drugs interacting with statins and knowledge of certain combinations together with monitoring of altered creatine kinase activity may greatly minimise associated adverse effects.
Molecular mechanisms of statin intolerance
- MedicineArchives of medical science : AMS
- 2016
In the case of most patients, it seems that mild-to-moderate abnormalities in liver and muscle enzymes are not serious adverse effects and do not outweigh the benefits of coronary heart disease risk reduction.
Risk identification and possible countermeasures for muscle adverse effects during statin therapy.
- Medicine, BiologyEuropean journal of internal medicine
- 2015
Management of statin intolerance
- MedicineIndian journal of endocrinology and metabolism
- 2013
Though statin intolerance has considerably impacted cardiovascular outcomes in the high-risk patients, it has been well effectively managed by prescribing statins either as alternate-day or once weekly dosage regimen, as combination therapy with a non-statin therapy or and by dietary intervention.
Statin Safety and Associated Adverse Events: A Scientific Statement From the American Heart Association
- MedicineArteriosclerosis, thrombosis, and vascular biology
- 2019
In patients for whom statin treatment is recommended by current guidelines, the benefits greatly outweigh the risks, and the difference in the incidence of muscle symptoms without significantly raised creatinine kinase in statin-treated compared with placebo-treated participants is <1%, suggesting that muscle symptoms are usually not caused by pharmacological effects of the statin.
References
SHOWING 1-10 OF 145 REFERENCES
The issue of statin safety: where do we stand?
- MedicineCirculation
- 2005
Side effects of statins tend to be dose related, and most side effects, including myopathy, disappear on withdrawal of the medication, although fatalities occasionally occur.
Statins and chronic heart failure: do we need a large-scale outcome trial?
- Biology, MedicineJournal of the American College of Cardiology
- 2002
Benefits and Risks of HMG-CoA Reductase Inhibitors in the Prevention of Coronary Heart Disease
- Medicine
- 1996
The Scandinavian Simvastatin Survival Study (4S) is the first trial of lipid-lowering therapy to demonstrate an unequivocal reduction in total mortality, and there is now little disagreement on the necessity to reduce low density lipoprotein (LDL) cholesterol effectively in hypercholesterolaemic patients with CHD.
Statin therapy in kidney disease populations: potential benefits beyond lipid lowering and the need for clinical trials
- Medicine, BiologyCurrent opinion in nephrology and hypertension
- 2004
Statins appear effective for the prevention of vascular events in people with established vascular disease and mild renal impairment, and may delay renal disease progression in such individuals, but there remains substantial uncertainty regarding the effects of statin therapy among patients with established chronic kidney disease.
Should patients with chronic heart failure be treated with "statins"?
- BiologyHeart failure monitor
- 2003
An answer to the question of whether or not therapy for CHF should include statins requires a definitive clinical trial, supported by the overriding observation that low plasma lipid levels portend a poorer prognosis in patients with established CHF.
Benefits and risks of HMG-CoA reductase inhibitors in the prevention of coronary heart disease: a reappraisal.
- MedicineDrug safety
- 1996
The Scandinavian Simvastatin Survival Study (4S) is the first trial of lipid-lowering therapy to demonstrate an unequivocal reduction in total mortality, and there is now little disagreement on the necessity to reduce low density lipoprotein (LDL) cholesterol effectively in hypercholesterolaemic patients with CHD.
MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial
- MedicineThe Lancet
- 2003
Statin safety: lessons from new drug applications for marketed statins.
- Biology, MedicineThe American journal of cardiology
- 2006
Intensive lipid lowering with atorvastatin in patients with stable coronary disease.
- MedicineThe New England journal of medicine
- 2005