The safety of antidepressant drugs during pregnancy
@article{Klln2007TheSO, title={The safety of antidepressant drugs during pregnancy}, author={Bengt K{\"a}ll{\'e}n}, journal={Expert Opinion on Drug Safety}, year={2007}, volume={6}, pages={357 - 370} }
This article discusses known or suspected effects of maternal use of antidepressants during pregnancy on pregnancy outcome. It is unlikely that any marked teratogenic effect occurs with the possible exception of an increased risk for cardiovascular defects after maternal use of clomipramine or paroxetine. An increased risk for preterm birth is seen. Transient neonatal symptoms are common after the use of antidepressants in late pregnancy. Few firm data are available on the possible impact on…
30 Citations
Maternal Use of Antidepressants and Infant Congenital Malformations
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If possible the two most suspected drugs (clomipramine and paroxetine) should be avoided but if exposure has already occurred, the risk is only moderately high and the involved cardiac defects are usually not very serious.
Delivery outcome after maternal use of antidepressant drugs in pregnancy: an update using Swedish data
- MedicinePsychological Medicine
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Women using antidepressants during pregnancy and their newborns have increased pathology, but it is not clear how much of this is due to drug use or underlying pathology.
Managing unipolar depression in pregnancy
- MedicineCurrent opinion in psychiatry
- 2009
Clinicians need to keep abreast of changes in the management of depression during pregnancy so that the most up-to-date recommendations may be provided to pregnant women.
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- Medicine
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The safety of different classes of antidepressants are evaluated and no convincing evidence of an increased risk for any adverse outcomes in an appreciable fashion is found.
Antidepressant use in pregnancy
- Medicine, PsychologyExpert opinion on drug safety
- 2011
The safety of different classes of antidepressants are evaluated and no convincing evidence of an increased risk for any adverse outcomes in an appreciable fashion is found.
Maternal Use of Antipsychotics in Early Pregnancy and Delivery Outcome
- MedicineJournal of clinical psychopharmacology
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There was a statistically significant increase in the risk for a congenital malformation-after exclusion of some common and minor conditions, and there seems to be little drug specificity, and it is possible that underlying pathology or unidentified confounding explains the excess risk.
Fetal exposure to neurotropic drugs : neonatal effects and long-term outcome
- Medicine, Psychology
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How neurotropic drugs and/or maternal chronic illness during pregnancy may influence the health of the child, both in the neonatal period and long-term outcome, with emphasis on neurodevelopment is described.
Antidepressant Use During Pregnancy and Asthma in the Offspring
- Medicine, PsychologyPediatrics
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Antidepressant use during pregnancy generally did not increase the risk of asthma, and only use of older antidepressants was associated with an increasedrisk of asthma.
Maternal use of selective serotonin re‐uptake inhibitors and persistent pulmonary hypertension of the newborn
- Medicine, PsychologyPharmacoepidemiology and drug safety
- 2008
The mechanism behind the association between SSRI and PPHN is unclear but an increased risk for respiratory problems after maternal use of SSRI is well known, and P PHN could be a rare part of this association.
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