The safety evaluation of food flavouring substances: the role of metabolic studies.

@article{Smith2018TheSE,
  title={The safety evaluation of food flavouring substances: the role of metabolic studies.},
  author={Robert L. Smith and Samuel M. Cohen and Shoji Fukushima and Nigel J. Gooderham and Stephen S. Hecht and F. Peter Guengerich and Ivonne M C M Rietjens and Maria Bastaki and Christie L Harman and Margaret M. McGowen and Sean V. Taylor},
  journal={Toxicology research},
  year={2018},
  volume={7 4},
  pages={
          618-646
        }
}
The safety assessment of a flavour substance examines several factors, including metabolic and physiological disposition data. The present article provides an overview of the metabolism and disposition of flavour substances by identifying general applicable principles of metabolism to illustrate how information on metabolic fate is taken into account in their safety evaluation. The metabolism of the majority of flavour substances involves a series both of enzymatic and non-enzymatic… 

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