The safety assessment of fragrance materials.

@article{Bickers2003TheSA,
  title={The safety assessment of fragrance materials.},
  author={David R. Bickers and Peter Calow and Helmut Greim and Jon Hanifin and Adrianne E. Rogers and Jean Hilaire Saurat and I Glenn Sipes and Robert L. Smith and Hachiro Tagami},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2003},
  volume={37 2},
  pages={
          218-73
        }
}
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102 Citations
Highly Influential Citations
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36
Methods Citations
5

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References

SHOWING 1-10 OF 57 REFERENCES

Criteria for development of a database for safety evaluation of fragrance ingredients.

This approach, specifically considering the dermal route of exposure as the most relevant one for fragrance ingredients, has been developed and is designed to be conservative but not so much so as to require excessive effort when not justified.

A framework for prioritizing fragrance materials for aquatic risk assessment

These combined exercises demonstrated the ability of this highly precautionary risk-based screening approach to quickly prioritize a large number of materials without benefit of experimental ecotoxicological or fate data.

Consumer exposure to fragrance ingredients: providing estimates for safety evaluation.

Estimates of exposure through different routes and leading to different potential endpoints indicate that deposition on the surface of the skin following use of cosmetics represents the major route of exposure to fragrance ingredients when conservative estimates for evaporation, rinsing, and other forms of product removal are employed.

Environmental risk assessment of musk ketone and musk xylene in The Netherlands in accordance with the EU-TGD.

Sensitization Methodology and Primary Prevention of the Research Institute for Fragrance Materials

In subjects where sensitization was induced by predictive testing, no serious recurring adverse dermatological conditions developed and most subjects were able to use a bar soap, a moisurizing lotion and cologne-type products with up to 1% hydroxycitronellal.

The FEMA GRAS assessment of alicyclic substances used as flavour ingredients.

  • T. AdamsJ. Hallagan R. A. Ford
  • Chemistry, Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1996

The importance of exposure estimation in the assessment of skin sensitization risk

The critical exposure determinant for evaluating skin sensitization risk is dose per unit area of skin exposed, and, at least for known potent allergens, there is remarkable similarity in threshold dose/unit area determinations across species.

Understanding fragrance allergy using an exposure‐based risk assessment approach

By estimating the exposure to the allergen and its allergenic potency, it is feasible to assess quantitatively the sensitization risk of an ingredient in a particular product type.

Environmental risk assessment for the polycyclic musks, AHTN and HHCB. II. Effect assessment and risk characterisation.

The Epidemiology of Fragrance Allergy: Questions and Needs

Both a ‘sentinel surveillance’ system and more refined epidemiological studies in well-defined populations are needed to reliably assess the risks associated with fragrance exposure and risk assessment requires that data from different sources are integrated and compared.
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