The safety assessment of fragrance materials.

@article{Bickers2003TheSA,
  title={The safety assessment of fragrance materials.},
  author={D. Bickers and P. Calow and H. Greim and J. Hanifin and A. E. Rogers and J. Saurat and I. Glenn Sipes and Robert L. Smith and H. Tagami},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2003},
  volume={37 2},
  pages={
          218-73
        }
}
Safety evaluation of the large number of diverse chemicals used as fragrance ingredients follows a systematic prioritization of data generation and analysis, consideration of exposure and critical analysis of the quality of the available information. [...] Key Result A discussion is provided of REXPAN's decision tree approach to assessing the dermal, systemic and environmental endpoints and the types and quality of data included.Expand
Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) safety evaluation process for fragrance ingredients.
  • A. Api, D. Belsito, +22 authors D. K. Wilcox
  • Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2015
TLDR
This publication is designed to update the RifM safety assessment process, which follows a series of decision trees, reflecting advances in approaches in risk assessment and new and classical toxicological methodologies employed by RIFM over the past ten years. Expand
Subject Area 7 – Risk Assessment , Risk Management , Health Issues Fragrances in the Environment : Pleasant Odours for Nature ? *
Goal, Scope and Background. Fragrance preparations or perfumes are used in an increasing variety of applications, as for example washing, cleansing, personal care products, consumer goods or inExpand
Application of the threshold of toxicological concern (TTC) to the safety evaluation of cosmetic ingredients.
The threshold of toxicological concern (TTC) has been used for the safety assessment of packaging migrants and flavouring agents that occur in food. The approach compares the estimated oral intakeExpand
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  • Medicine
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  • 2021
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The 167 materials identified in this assessment were evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety and showed that these materials are not expected to be genotoxic. Expand
Fragrances in the Environment: Pleasant odours for nature? (9 pp)
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The interdisciplinary approach, bringing together chemical, biological, toxicological and ecotoxicological data with information provided by manufacturers and with legal and consumer aspects, offers new insights into the field of fragrance substances used in consumer products. Expand
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  • Medicine
  • International journal of hygiene and environmental health
  • 2010
TLDR
The evaluation of "the 26 allergens rule" is an example which can be transferred to other regulations and which could help to improve future regulatory approaches, with a focus on the roles authorities, manufacturers and consumers play in a promising risk management. Expand
Macrocyclic fragrance materials--a screening-level environmental assessment using chemical categorization.
TLDR
The results of this screening-level aquatic ecological risk assessment indicate that at their current tonnage, often referred to as volumes of use, macrocyclic fragrance materials in Europe and North America, pose a negligible risk to aquatic biota; with no PEC/PNEC ratio exceeding 1 for any material in any subgroup. Expand
Identification of potential PBT behavior of personal care products by structural approaches
Abstract Several organic ingredients in personal care products (PCPs) became recently compounds of increasing environmental concern, being frequently detected mainly in receiving waters. However,Expand
Peroxide levels along the fragrance value chain comply with IFRA standards
Autoxidation of certain perfume ingredients can result in the formation of sensitizing chemicals although the parent compounds are non-sensitizing. Peroxide values were determined for 875 freshlyExpand
Skin Sensitization Induction Risk Assessment of Common Ingredients in Commercially Available Cleansing Conditioners
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This analysis indicates that exposure to the individual ingredients present in these cleansing conditioners would not be expected to induce dermal sensitization in a consumer under the examined exposure scenario. Expand
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References

SHOWING 1-10 OF 58 REFERENCES
Criteria for development of a database for safety evaluation of fragrance ingredients.
TLDR
This approach, specifically considering the dermal route of exposure as the most relevant one for fragrance ingredients, has been developed and is designed to be conservative but not so much so as to require excessive effort when not justified. Expand
A framework for prioritizing fragrance materials for aquatic risk assessment.
TLDR
These combined exercises demonstrated the ability of this highly precautionary risk-based screening approach to quickly prioritize a large number of materials without benefit of experimental ecotoxicological or fate data. Expand
Consumer exposure to fragrance ingredients: providing estimates for safety evaluation.
TLDR
Estimates of exposure through different routes and leading to different potential endpoints indicate that deposition on the surface of the skin following use of cosmetics represents the major route of exposure to fragrance ingredients when conservative estimates for evaporation, rinsing, and other forms of product removal are employed. Expand
Environmental risk assessment of musk ketone and musk xylene in The Netherlands in accordance with the EU-TGD.
TLDR
The risk assessment provides reassurance for the aquatic compartment while pointing the way for obtaining additional data for the soil compartment, and the reliability of the predicted soil concentrations can be greatly improved by obtaining experimental data on fate and behaviour of musk ketone and musk xylene in digested sludge and soil. Expand
Sensitization Methodology and Primary Prevention of the Research Institute for Fragrance Materials
TLDR
In subjects where sensitization was induced by predictive testing, no serious recurring adverse dermatological conditions developed and most subjects were able to use a bar soap, a moisurizing lotion and cologne-type products with up to 1% hydroxycitronellal. Expand
The FEMA GRAS assessment of alicyclic substances used as flavour ingredients.
  • T. Adams, J. Hallagan, +10 authors R. A. Ford
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1996
TLDR
The elements of the GRAS assessment program as they have been applied by the Expert Panel to the group of 119 alicyclic substances used as flavour ingredients, and the relevant scientific data which provide the basis for theGRAS status of these substances are described herein. Expand
The importance of exposure estimation in the assessment of skin sensitization risk
TLDR
The critical exposure determinant for evaluating skin sensitization risk is dose per unit area of skin exposed, and, at least for known potent allergens, there is remarkable similarity in threshold dose/unit area determinations across species. Expand
Understanding fragrance allergy using an exposure‐based risk assessment approach
TLDR
By estimating the exposure to the allergen and its allergenic potency, it is feasible to assess quantitatively the sensitization risk of an ingredient in a particular product type. Expand
Environmental risk assessment for the polycyclic musks, AHTN and HHCB. II. Effect assessment and risk characterisation.
TLDR
Reports of the polycyclic musks AHTN and HHCB in surface water and fish, primarily in Europe, have prompted studies of their environmental effects, leading to Predicted No Effect Concentrations (PNEC) of 3.5 microg/l (AHTN) and 6.8 microg /l (HHCB) for aquatic organisms. Expand
The Epidemiology of Fragrance Allergy: Questions and Needs
TLDR
Both a ‘sentinel surveillance’ system and more refined epidemiological studies in well-defined populations are needed to reliably assess the risks associated with fragrance exposure and risk assessment requires that data from different sources are integrated and compared. Expand
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