The safety assessment of fragrance materials.

@article{Bickers2003TheSA,
  title={The safety assessment of fragrance materials.},
  author={D. Bickers and P. Calow and H. Greim and J. Hanifin and A. E. Rogers and J. Saurat and I. Glenn Sipes and Robert L. Smith and H. Tagami},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2003},
  volume={37 2},
  pages={
          218-73
        }
}
Safety evaluation of the large number of diverse chemicals used as fragrance ingredients follows a systematic prioritization of data generation and analysis, consideration of exposure and critical analysis of the quality of the available information. [...] Key Result A discussion is provided of REXPAN's decision tree approach to assessing the dermal, systemic and environmental endpoints and the types and quality of data included.Expand
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fragrancematerialsafetyresource.elsevier.com
96 Citations
Highly Influential Citations
7
Background Citations
34
Methods Citations
5

96 Citations

Citation Type

Citation Type

Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) safety evaluation process for fragrance ingredients.
  • A. Api, D. Belsito, +22 authors D. K. Wilcox
  • Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2015
TLDR
This publication is designed to update the RifM safety assessment process, which follows a series of decision trees, reflecting advances in approaches in risk assessment and new and classical toxicological methodologies employed by RIFM over the past ten years. Expand
Subject Area 7 – Risk Assessment , Risk Management , Health Issues Fragrances in the Environment : Pleasant Odours for Nature ? *
Goal, Scope and Background. Fragrance preparations or perfumes are used in an increasing variety of applications, as for example washing, cleansing, personal care products, consumer goods or in… Expand
Application of the threshold of toxicological concern (TTC) to the safety evaluation of cosmetic ingredients.
The threshold of toxicological concern (TTC) has been used for the safety assessment of packaging migrants and flavouring agents that occur in food. The approach compares the estimated oral intake… Expand
RIFM low-exposure fragrance ingredients safety assessment.
  • A. Api, D. Belsito, +32 authors S. Tsang
  • Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2021
TLDR
The 167 materials identified in this assessment were evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety and showed that these materials are not expected to be genotoxic. Expand
Fragrances in the Environment: Pleasant odours for nature? (9 pp)
TLDR
The interdisciplinary approach, bringing together chemical, biological, toxicological and ecotoxicological data with information provided by manufacturers and with legal and consumer aspects, offers new insights into the field of fragrance substances used in consumer products. Expand
Risk management by labelling 26 fragrances? Evaluation of Article 10 (1) of the seventh Amendment (Guideline 2003/15/EC) of the Cosmetic Directive.
  • U. Klaschka
  • Medicine
  • International journal of hygiene and environmental health
  • 2010
TLDR
The evaluation of "the 26 allergens rule" is an example which can be transferred to other regulations and which could help to improve future regulatory approaches, with a focus on the roles authorities, manufacturers and consumers play in a promising risk management. Expand
Macrocyclic fragrance materials--a screening-level environmental assessment using chemical categorization.
TLDR
The results of this screening-level aquatic ecological risk assessment indicate that at their current tonnage, often referred to as volumes of use, macrocyclic fragrance materials in Europe and North America, pose a negligible risk to aquatic biota; with no PEC/PNEC ratio exceeding 1 for any material in any subgroup. Expand
Identification of potential PBT behavior of personal care products by structural approaches
Abstract Several organic ingredients in personal care products (PCPs) became recently compounds of increasing environmental concern, being frequently detected mainly in receiving waters. However,… Expand
Peroxide levels along the fragrance value chain comply with IFRA standards
Autoxidation of certain perfume ingredients can result in the formation of sensitizing chemicals although the parent compounds are non-sensitizing. Peroxide values were determined for 875 freshly… Expand
Skin Sensitization Induction Risk Assessment of Common Ingredients in Commercially Available Cleansing Conditioners
TLDR
This analysis indicates that exposure to the individual ingredients present in these cleansing conditioners would not be expected to induce dermal sensitization in a consumer under the examined exposure scenario. Expand
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