The safety and efficacy of combined amitriptyline and tranylcypromine antidepressant treatment. A controlled trial.

@article{Razani1983TheSA,
  title={The safety and efficacy of combined amitriptyline and tranylcypromine antidepressant treatment. A controlled trial.},
  author={Javad Razani and Kathryn L White and Jacqueline M. White and George M. Simpson and R. Bruce Sloane and R F Rebal and Ruby Palmer},
  journal={Archives of general psychiatry},
  year={1983},
  volume={40 6},
  pages={657-61}
}
Sixty patients meeting DSM-III criteria for major depression were assigned randomly to double-blind treatment for four weeks according to fixed-dosage steps with (1) amitriptyline hydrochloride alone, up to a maximum dosage of 300 mg/day; (2) tranylcypromine alone, up to 40 mg/day; or (3) the combination of amitriptyline hydrochloride, up to 150 mg/day, and tranylcypromine, up to 20 mg/day. The conditions of patients in all three treatment groups improved equally. The combined treatment did not… CONTINUE READING