The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men.

@article{Basaria2013TheSP,
  title={The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men.},
  author={Shehzad S Basaria and Lauren G Collins and Edgar Lichar Dillon and Katie Orwoll and Thomas Storer and Renee Miciek and Jagadish N Ulloor and Anqi Zhang and Richard V Eder and Heather Zientek and Gilad Gordon and Syed Sajjad Nasir Kazmi and Melinda Sheffield-Moore and Shalender Bhasin},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2013},
  volume={68 1},
  pages={87-95}
}
BACKGROUND Concerns about potential adverse effects of testosterone on prostate have motivated the development of selective androgen receptor modulators that display tissue-selective activation of androgenic signaling. LGD-4033, a novel nonsteroidal, oral selective androgen receptor modulator, binds androgen receptor with high affinity and selectivity. Objectives. To evaluate the safety, tolerability, pharmacokinetics, and effects of ascending doses of LGD-4033 administered daily for 21 days on… CONTINUE READING

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