The ryanodine receptor in cardiac physiology and disease.

  title={The ryanodine receptor in cardiac physiology and disease.},
  author={Alexander Kushnir and Andrew Robert Marks},
  journal={Advances in pharmacology},
According to the American Heart Association it is estimated that the United States will spend close to $39 billion in 2010 to treat over five million Americans suffering from heart failure. Patients with heart failure suffer from dyspnea and decreased exercised tolerance and are at increased risk for fatal ventricular arrhythmias. Food and Drug Administration -approved pharmacologic therapies for heart failure include diuretics, inhibitors of the renin-angiotensin system, and β-adrenergic… CONTINUE READING