The rs4774 CIITA missense variant is associated with risk of systemic lupus erythematosus

@article{Bronson2011TheRC,
  title={The rs4774 CIITA missense variant is associated with risk of systemic lupus erythematosus},
  author={Paola G Bronson and Benjamin A. Goldstein and Patricia Pamela Ramsay and Kenneth Beckman and Janelle A. Noble and Julie A. Lane and Michael F. Seldin and Jennifer A. Kelly and John Barker Harley and Kathy L. Moser and Patrick M Gaffney and Timothy W. Behrens and Lindsey A. Criswell and Lisa F. Barcellos},
  journal={Genes and Immunity},
  year={2011},
  volume={12},
  pages={667-671}
}
The major histocompatibility complex (MHC) class II transactivator gene (CIITA) encodes an important transcription factor required for human leukocyte antigens (HLA) class II MHC-restricted antigen presentation. MHC genes, including the HLA class II DRB1*03:01 allele, are strongly associated with systemic lupus erythematosus (SLE). Recently the rs4774 CIITA… CONTINUE READING