The round window membrane in otitis media: effect of pneumococcal proteins.

  title={The round window membrane in otitis media: effect of pneumococcal proteins.},
  author={Patricia A. Schachern and Vladimir Tsuprun and Sebahattin Cureoglu and Patricia A Ferrieri and David E. Briles and Michael Mauro Paparella and Steven K. Juhn},
  journal={Archives of otolaryngology--head & neck surgery},
  volume={134 6},
OBJECTIVE To determine whether mutants of Streptococcus pneumoniae that are deficient in pneumococcal surface protein A (PspA), pneumococcal surface antigen A (PsaA), or pneumolysin (Ply) are less virulent and less likely to penetrate the round window membrane (RWM). DESIGN Histopathologic comparison of wild-type S. pneumoniae and its mutants deficient in PspA, PsaA, and Ply. SETTING Otopathology Laboratory, Department of Otolaryngology, University of Minnesota Medical School, Minneapolis… CONTINUE READING


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