The rostral migratory stream in adult squirrel monkeys: contribution of new neurons to the olfactory tubercle and involvement of the antiapoptotic protein Bcl‐2

  title={The rostral migratory stream in adult squirrel monkeys: contribution of new neurons to the olfactory tubercle and involvement of the antiapoptotic protein Bcl‐2},
  author={Andr{\'e}anne B{\'e}dard and Martin L{\'e}vesque and Patrick J. Bernier and André Parent},
  journal={European Journal of Neuroscience},
The subventricular zone (SVZ) lying along the ependymal layer of lateral ventricle is known to generate neural progenitor cells throughout adulthood in specific areas of the mammalian brain. In rodents, the anterior region of the SVZ produces neuroblasts that migrate in chain toward the olfactory bulb along the so‐called rostral migratory stream (RMS). In the present study, the organization of the RMS in a representative of New World primates – the squirrel monkey (Saimiri sciureus) – was… 

Identification of the Rostral Migratory Stream in the Canine and Feline Brain

In the adult rodent brain, neural progenitor cells migrate from the subventricular zone of the lateral ventricle towards the olfactory bulb in a track known as the rostral migratory stream (RMS). To

Evidence of newly generated neurons in the human olfactory bulb.

Subventricular zone‐derived neuronal progenitors migrate into the subcortical forebrain of postnatal mice

It is demonstrated that in early postnatal and, to a minor extent in adult mice, SVZ‐derived cells contribute new neurons to the subcortical forebrain.

Neurogenesis in Monkey and Human Adult Brain

The striatum of normal adult squirrel monkeys was found to harbor newly generated cells that eventually become projection neurons, a finding that raises hope for the development of novel therapeutic approaches for the treatment of ­certain neurodegenerative diseases.

Identification and characterization of neuroblasts in the subventricular zone and rostral migratory stream of the adult human brain

Evidence that neuroblasts exist continuously in the anterior ventral SVZ and RMS of the adult human brain is provided and the data suggest that the SVZ maintains the ability to produce neuroblast in the adulthuman brain.

The microtubule protein Doublecortin contributes to maintenance of bipolar shape and nuclear translocation during neuronal migration in the adult forebrain

This work shows that Doublecortin (DCX), a widely used marker for newly generated neurons, when deleted in mouse results in a severe morphological defect in the rostral migratory stream and delayed neuronal migration that is independent of direction or responsiveness to Slit chemorepulsion.

Neurogenesis of medium spiny neurons in the nucleus accumbens continues into adulthood and is enhanced by pathological pain

Using several in vivo mouse models, it is shown that newborn neurons integrate into preexisting circuits in the NAc where they mature as medium spiny neurons (MSNs), i.e., a type of projection neurons formerly believed to be generated only during embryonic development.

Human and Monkey Striatal Interneurons Are Derived from the Medial Ganglionic Eminence But Not from the Adult Subventricular Zone

Although a small number of neuroblasts exist in the adult human SVZ, they do not migrate into the striatum and become mature striatal interneurons, providing strong evidence that the vast majority of interneuron are generated from the medial ganglionic eminence during embryonic developmental stages, as they are in rodents.

Dynamic Changes in the Neurogenic Potential in the Ventricular-Subventricular Zone of Common Marmoset during Postnatal Brain Development.

Using marmosets injected with thymidine analogue(s) during various postnatal periods, this work demonstrated spatiotemporal changes in neurogenesis during development in primates and shed light on distinctive features of postnatal Neurogenesis in primates.



Newly generated neurons in the amygdala and adjoining cortex of adult primates

The production of newborn neurons in the amygdala, piriform cortex, and inferior temporal cortex seems to parallel the continuing addition of neurons inThe olfactory bulb, and these two concomitant phenomena may ensure structural stability and functional plasticity to the primate Olfactory system and temporal lobe.

The generation, migration, and differentiation of olfactory neurons in the adult primate brain

  • D. R. KornackP. Rakić
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2001
Results indicate that dividing cells in the adult monkey SZ generate neuroblasts that undergo restricted chain migration over an extended distance of more than 2 cm to the OB and differentiate into granule interneurons, which support the use of the SZ/RMS as a model system for studying neural regenerative mechanisms in the human brain.

Network of tangential pathways for neuronal migration in adult mammalian brain.

It is demonstrated that cells originating at different rostrocaudal levels of the SVZ migrate rostrally and reach the olfactory bulb where they differentiate into neurons.

Cellular Composition and Three-Dimensional Organization of the Subventricular Germinal Zone in the Adult Mammalian Brain

The results suggest that chains of migrating neuroblasts in the SVZ may be derived from Type C cells, which had immature ultrastructural characteristics and were nestin-positive but negative to the other markers.

Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb

  • J. Altman
  • Biology
    The Journal of comparative neurology
  • 1969
The results established that the major target structure of cell production in the subependymal layer of the lateral ventricle in young‐adult rats is the olfactory bulb, with only moderate contribution made to the anterior neocortex and basal ganglia.

Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation

It is confirmed that in the adult rat brain, neuronal progenitor cells divide at the border between the hilus and the granule cell layer (GCL) and in adult rats, the progeny of these cells migrate into the GCL and express the neuronal markers NeuN and calbindin-D28k.

The Division of Neuronal Progenitor Cells during Migration in the Neonatal Mammalian Forebrain

Using lineage tracers and the cell proliferation marker BrdU, it is demonstrated that SVZa-derived cells in the rat retain the capacity for division after migrating away from their initial site of generation, suggesting that, unlike other immature neurons, these SVZas have made a commitment to become neurons before becoming postmitotic.

Widespread expression of rat collapsin response‐mediated protein 4 in the telencephalon and other areas of the adult rat central nervous system

The results of this study suggest that rCRMP‐4 expression in the CNS is associated with cells that are migrating or are undergoing axonal growth.