The roles of troponin C isoforms in the mechanical function of Drosophila indirect flight muscle

@article{Eldred2014TheRO,
  title={The roles of troponin C isoforms in the mechanical function of Drosophila indirect flight muscle},
  author={Catherine C. Eldred and Anja Katzemich and Monica Bhupendra Patel and Belinda Bullard and Douglas M Swank},
  journal={Journal of Muscle Research and Cell Motility},
  year={2014},
  volume={35},
  pages={211-223}
}
Stretch activation (SA) is a fundamental property of all muscle types that increases power output and efficiency, yet its mechanism is unknown. Recently, studies have implicated troponin isoforms as important in the SA mechanism. The highly stretch-activated Drosophila IFMs express two isoforms of the Ca2+-binding subunit of troponin (TnC). TnC1 (TnC-F2 in Lethocerus IFM) has two calcium binding sites, while an unusual isoform, TnC4 (TnC-F1 in Lethocerus IFM), has only one binding site. We… CONTINUE READING
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