The roles of transporters and enzymes in hepatic drug processing.

Abstract

A simple, physiological model was used to illustrate the competing nature of transporters and metabolic enzymes in hepatic drug processing. Enalapril, a drug whose basolateral influx and canalicular efflux are mediated by rat organic anion-transporting polypeptide 1 (Oatp1) and rat multidrug resistance-associated protein 2 (Mrp2), respectively, and… (More)

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@article{Liu2005TheRO, title={The roles of transporters and enzymes in hepatic drug processing.}, author={Lichuan Liu and K. Sandy Pang}, journal={Drug metabolism and disposition: the biological fate of chemicals}, year={2005}, volume={33 1}, pages={1-9} }