The roles of transforming growth factor-β and Smad3 signaling in adipocyte differentiation and obesity.

Abstract

We aimed at elucidating the roles of transforming growth factor (TGF)-β and Smad3 signaling in adipocyte differentiation (adipogenesis) and in the pathogenesis of obesity. TGF-β/Smad3 signaling in white adipose tissue (WAT) was determined in genetically obese (ob/ob) mice. The effect of TGF-β on adipogenesis was evaluated in mouse embryonic fibroblasts (MEF… (More)
DOI: 10.1016/j.bbrc.2011.02.106

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@article{Tsurutani2011TheRO, title={The roles of transforming growth factor-β and Smad3 signaling in adipocyte differentiation and obesity.}, author={Yuya Tsurutani and Masaki Fujimoto and Minoru Takemoto and Hiroki Irisuna and Masaya Koshizaka and Shunichiro Onishi and Takahiro Ishikawa and Morito Mezawa and Peng He and Satoshi Honjo and Yoshiro Maezawa and Yasushi Saito and Koutaro Yokote}, journal={Biochemical and biophysical research communications}, year={2011}, volume={407 1}, pages={68-73} }