The roles of therapy-induced autophagy and necrosis in cancer treatment.

@article{Amaravadi2007TheRO,
  title={The roles of therapy-induced autophagy and necrosis in cancer treatment.},
  author={Ravi K Amaravadi and Craig B Thompson},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2007},
  volume={13 24},
  pages={
          7271-9
        }
}
Metabolic and therapeutic stresses activate several signal transduction pathways that regulate cell death and cell survival in cancer cells. Although decades of research unraveled the pathways that regulate apoptosis and allowed the development of novel diagnostic and therapeutic modalities in cancer treatment, only recently has the regulation and significance of tumor cell autophagy and necrosis become the focus of investigations. Necrosis is an irreversible inflammatory form of cell death. In… CONTINUE READING

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