The roles of the residues on the channel beta-hairpin and loop structures of simian virus 40 hexameric helicase.

@article{Shen2005TheRO,
  title={The roles of the residues on the channel beta-hairpin and loop structures of simian virus 40 hexameric helicase.},
  author={Jingping Shen and D. Lopez Gai and Aaron Patrick and William B Greenleaf and Xiaojiang S. Chen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 32},
  pages={11248-53}
}
Simian virus 40 large tumor antigen is required for DNA unwinding during viral replication. The helicase-active form of large tumor antigen is a ring-shaped hexamer/double hexamer, which has a positively charged hexameric channel for interacting with DNA. On the hexameric channel surface are six beta-hairpin structures and loops, emanating from each of the six subunits. At the tips of the beta-hairpin and the loop structures are two ring-shaped residues, H513 and F459, respectively… CONTINUE READING

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