• Biology, Medicine
  • Published in
    Biochemistry and cell biology…
    2005
  • DOI:10.1139/o05-064

The roles of the human lipid-binding proteins ORP9S and ORP10S in vesicular transport.

@article{Fairn2005TheRO,
  title={The roles of the human lipid-binding proteins ORP9S and ORP10S in vesicular transport.},
  author={Gregory D Fairn and Christopher R McMaster},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  year={2005},
  volume={83 5},
  pages={
          631-6
        }
}
Inactivation of the yeast oxysterol binding protein related protein (ORP) family member Kes1p allows yeast cells to survive in the absence of Sec14p, a phospholipid transfer protein required for cell viability because of the role it plays in transporting vesicles from the Golgi. We expressed human ORP9S and ORP10S in yeast lacking Sec14p and Kes1p function, and found that ORP9S completely complemented Kes1p function, whereas ORP10S possessed only a weak ability to replace Kes1p function… CONTINUE READING

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