The roles of the COX2/PGE2/EP axis in therapeutic resistance

@article{Tong2018TheRO,
  title={The roles of the COX2/PGE2/EP axis in therapeutic resistance},
  author={Dali Tong and Qiuli Liu and Lin-ang Wang and Qiubo Xie and Jian Pang and Yiqiang Huang and Luofu Wang and Gaolei Liu and Dianzheng Zhang and Weihua Lan and Jun Jiang},
  journal={Cancer and Metastasis Reviews},
  year={2018},
  volume={37},
  pages={355-368}
}
Therapeutic resistance has been and remains to be the major challenge in developing successful treatments for different cancers and therefore, understanding the underlying mechanisms in the development of therapeutic resistance is crucial in combating cancers. Multiple mechanisms underlie the development of therapeutic resistance, and the signaling pathways involved in cancer stem cell repopulation, enhanced epithelial-mesenchymal transition (EMT), inflammatory infiltration, and… CONTINUE READING
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