The roles of telomeres and telomerase in cellular immortalization and the development of cancer.

Abstract

Normal human cells have a limited lifespan in culture called the Hayflick limit. Recent studies have indicated that telomere shortening is one of the important meters utilized by cells to determine the Hayflick limit, and that activation of a mechanism to maintain telomere length is essential for cells to become immortal. It is generally believed that cells… (More)

Topics

Cite this paper

@article{Klingelhutz1999TheRO, title={The roles of telomeres and telomerase in cellular immortalization and the development of cancer.}, author={Aloysius J. Klingelhutz}, journal={Anticancer research}, year={1999}, volume={19 6A}, pages={4823-30} }