The roles of prostanoids in infection and sickness behaviors

  title={The roles of prostanoids in infection and sickness behaviors},
  author={Toshiyuki Matsuoka and S. Narumiya},
  journal={Journal of Infection and Chemotherapy},
  • Toshiyuki Matsuoka, S. Narumiya
  • Published 2008
  • Medicine
  • Journal of Infection and Chemotherapy
  • A systemic infection in patients causes so-called sickness behaviors, such as fever generation, adrenocorticotropic hormone release, reduced locomotion, loss of social contact, anorexia, and increased sleep. As aspirin-like non-steroidal anti-inflammatory drugs alleviate most of these symptoms, the involvement of prostanoids in the generation of sickness behaviors has been strongly suggested. Prostanoids, consisting of prostaglandins (PGs) and thromboxanes (TXs), are a group of lipid mediators… CONTINUE READING
    23 Citations
    PGI2 as a Regulator of Inflammatory Diseases
    • 76
    • PDF
    Molecular biology of histidine decarboxylase and prostaglandin receptors
    • 27
    • PDF
    Prostaglandin I2-IP signalling regulates human Th17 and Treg cell differentiation.
    • 13
    Time-dependent mediators of HPA axis activation following live Escherichia coli.
    • 25
    • PDF
    PGI2 signaling inhibits antigen uptake and increases migration of immature dendritic cells
    • 12


    Prostanoid receptors: structures, properties, and functions.
    • 2,317
    • PDF
    Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3
    • 633
    • Highly Influential
    Thromboxane A2 and prostaglandin F2α mediate inflammatory tachycardia
    • 119
    Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia.
    • 64
    • Highly Influential
    Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes
    • 100
    • Highly Influential
    • PDF
    Biochemical, structural, genetic, physiological, and pathophysiological features of lipocalin-type prostaglandin D synthase.
    • 312
    Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2
    • 996
    • PDF
    Cyclooxygenases 1 and 2.
    • 2,645
    Cyclooxygenases: structural, cellular, and molecular biology.
    • 2,575
    • PDF