The roles of prostanoids in infection and sickness behaviors

@article{Matsuoka2008TheRO,
  title={The roles of prostanoids in infection and sickness behaviors},
  author={Toshiyuki Matsuoka and Shuh Narumiya},
  journal={Journal of Infection and Chemotherapy},
  year={2008},
  volume={14},
  pages={270-278}
}
A systemic infection in patients causes so-called sickness behaviors, such as fever generation, adrenocorticotropic hormone release, reduced locomotion, loss of social contact, anorexia, and increased sleep. As aspirin-like non-steroidal anti-inflammatory drugs alleviate most of these symptoms, the involvement of prostanoids in the generation of sickness behaviors has been strongly suggested. Prostanoids, consisting of prostaglandins (PGs) and thromboxanes (TXs), are a group of lipid mediators… 
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