The roles of phospholipase D in EGFR signaling.

  title={The roles of phospholipase D in EGFR signaling.},
  author={Chang Sup Lee and Kyung Lock Kim and Jin Jang and Yoon Sup Choi and Pann Ghill Suh and Sung Ho Ryu},
  journal={Biochimica et biophysica acta},
  volume={1791 9},
Epidermal growth factor receptor (EGFR) is a representative model of receptor tyrosine kinases (RTKs), and offers a means of understanding their common principles and fundamental mechanisms. Furthermore, EGFR plays an essential role in cell proliferation and migration, and the disruption of EGFR signaling has been implicated in the development and growth of cancer. Phospholipase D (PLD) is a key mediator of EGFR function, and can be directly regulated by upstream binding partners in an EGF… CONTINUE READING

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