The roles of myeloperoxidase in coronary artery disease and its potential implication in plaque rupture

  title={The roles of myeloperoxidase in coronary artery disease and its potential implication in plaque rupture},
  author={N. Teng and G. Maghzal and Jihan Talib and Imran Rashid and A. Lau and R. Stocker},
  journal={Redox Report : Communications in Free Radical Research},
  pages={51 - 73}
  • N. Teng, G. Maghzal, +3 authors R. Stocker
  • Published 2017
  • Medicine
  • Redox Report : Communications in Free Radical Research
  • ABSTRACT Atherosclerosis is the main pathophysiological process underlying coronary artery disease (CAD). Acute complications of atherosclerosis, such as myocardial infarction, are caused by the rupture of vulnerable atherosclerotic plaques, which are characterized by thin, highly inflamed, and collagen-poor fibrous caps. Several lines of evidence mechanistically link the heme peroxidase myeloperoxidase (MPO), inflammation as well as acute and chronic manifestations of atherosclerosis. MPO and… CONTINUE READING
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