The roles of mucD and alginate in the virulence of Pseudomonas aeruginosa in plants, nematodes and mice.

@article{Yorgey2001TheRO,
  title={The roles of mucD and alginate in the virulence of Pseudomonas aeruginosa in plants, nematodes and mice.},
  author={Peter Yorgey and Laurence G Rahme and Michelle Wendy Tan and Frederick M. Ausubel},
  journal={Molecular microbiology},
  year={2001},
  volume={41 5},
  pages={1063-76}
}
We are exploiting the broad host range of the human opportunistic pathogen Pseudomonas aeruginosa strain PA14 to elucidate the molecular basis of bacterial virulence in plants, nematodes, insects and mice. In this report, we characterize the role that two PA14 gene products, MucD and AlgD, play in virulence. MucD is orthologous to the Escherichia coli periplasmic protease and chaperone DegP. DegP homologues are known virulence factors that play a protective role in stress responses in various… CONTINUE READING

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