The roles of microtubule-associated proteins in brain morphogenesis: a review

  title={The roles of microtubule-associated proteins in brain morphogenesis: a review},
  author={Richard P. Tucker},
  journal={Brain Research Reviews},
  • R. Tucker
  • Published 1 May 1990
  • Biology, Chemistry
  • Brain Research Reviews

Microtubule-associated proteins and neuronal morphogenesis

  • A. Matus
  • Biology
    Journal of Cell Science
  • 1991
The microtubule-associated proteins are a set of structural proteins that bind to microtubules in vitro that occur at high levels in neurons where their expression is under strong developmental regulation, suggesting that they are involved in neuronal morphogenesis.

Regulation of microtubule dynamics by microtubule-associated protein expression and phosphorylation during neuronal development.

Recent advances in the understanding of the molecular properties of major neuronal MAPs which may be relevant to neuronal development and synaptic plasticity are focused on.

Changes of MAP2 phosphorylation during brain development.

It is demonstrated that the immunocytochemical detection of MAP2 depends on modifications such as phosphorylation and conformational changes of the molecule, and that MAP2 staining patterns differ between MAbs.

Making sense of the multiple MAP-2 transcripts and their role in the neuron

The expression, localization, and possible functions of the newly identified spliced forms of the major MAP-2 forms are the focus of this review.

Microtubule-associated protein 2 and the organization of cellular microtubules

It is suggested that the induction of stiff microtubule bundles by MAP2, coupled with a breach in the cortical actin network, can confer two of the properties characteristic of neuronal processes; their cylindrical form and the presence of fasciculated microtubules.



MAP5: A novel brain microtubule-associated protein under strong developmental regulation

Immunoperoxidase staining of brain sections showed that MAP5 is present in neurons throughout the brain and that in them it is evenly distributed throughout axons, dendrites and cell bodies, which suggests thatMAP5 is particularly important in modulating microtubule function during the formation of neuronal processes.

Differences in the developmental patterns of three microtubule- associated proteins in the rat cerebellum

Results indicate that the combined appearance of MAP1 and MAP2 (dendrites) or MAP1 or MAP3 (axons) correlates with the appearance of morphologically distinct microtubules and provide further evidence that specific MAPs are molecular determinants of dendritic and axonal formation.

Developmental regulation of two microtubule-associated proteins (MAP2 and MAP5) in the embryonic avian retina.

The cellular distribution, developmental regulation and molecular forms of MAP2 and MAP5 are similar in the rat and quail, suggesting that these molecules have conserved and hence fundamental roles in the growth and differentiation of neuronal processes.

The novel microtubule-associated protein MAP3 contributes to the in vitro assembly of brain microtubules.

It is concluded that MAP3 contributes to the net assembly of brain microtubules observed in vitro, and may be particularly relevant in neonatal animals where brain MAP3 is more abundant than in the adult.

Heterogeneity of microtubule-associated proteins and brain development.

The data demonstrate the existence of two types of heterogeneity of microtubule-associated proteins: plurality of protein species at every stage of brain development and changes in composition and activity dependent on development.

Microtubule-associated protein 1B: identification of a major component of the neuronal cytoskeleton.

Immunofluorescence microscopy of rat brain sections and cultured rat brain cells indicated that compared to MAP 1A and MAP 2, MAP 1B was particularly prominent in axonal as well as dendritic processes, indicating thatMAP 1B is a major, previously undescribed component of the neuronal cytoskeleton.

Differential Localization of MAP‐2 and Tau in Mammalian Neurons in Situ a

The present monograph outlines the initial immunohistochemical and biochemical localization experiments using monoclonal antibodies to MAP-2 and tau in both adult and developing brain and raises the possibility that they may be differentially compartmentalized in brain tissue.