The roles of membrane microdomains (rafts) in T cell activation.

@article{Horejs2003TheRO,
  title={The roles of membrane microdomains (rafts) in T cell activation.},
  author={V{\'a}clav Hor̆ejs̆{\'i}},
  journal={Immunological reviews},
  year={2003},
  volume={191},
  pages={148-64}
}
Detergent-resistant membrane microdomains enriched in sphingolipids, cholesterol and glycosylphosphatidylinositol-anchored proteins play essential roles in T cell receptor (TCR) signaling. These 'membrane rafts' accumulate several cytoplasmic lipid-modified molecules, including Src-family kinases, coreceptors CD4 and CD8 and transmembrane adapters LAT and PAG/Cbp, essential for either initiation or amplification of the signaling process, while most other abundant transmembrane proteins are… CONTINUE READING

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