The roles of membrane microdomains (rafts) in T cell activation.

  title={The roles of membrane microdomains (rafts) in T cell activation.},
  author={V{\'a}clav Hor̆ejs̆{\'i}},
  journal={Immunological reviews},
Detergent-resistant membrane microdomains enriched in sphingolipids, cholesterol and glycosylphosphatidylinositol-anchored proteins play essential roles in T cell receptor (TCR) signaling. These 'membrane rafts' accumulate several cytoplasmic lipid-modified molecules, including Src-family kinases, coreceptors CD4 and CD8 and transmembrane adapters LAT and PAG/Cbp, essential for either initiation or amplification of the signaling process, while most other abundant transmembrane proteins are… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 48 extracted citations

Fatty acids and the immune system: from basic science to clinical applications.

The Proceedings of the Nutrition Society • 2004
View 4 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 250 references

Lipid rafts and T cell receptor signaling: a critical re-evaluation.

European journal of immunology • 2002
View 3 Excerpts
Highly Influenced

Activation of the COOHterminal Src kinase (Csk) by cAMPdependent protein kinase inhibits signaling through the T cell receptor

T Vang
J Exp Med • 2001
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…