The roles of intracellular protein-degradation pathways in neurodegeneration

  title={The roles of intracellular protein-degradation pathways in neurodegeneration},
  author={D. Rubinsztein},
  • D. Rubinsztein
  • Published 2006
  • Biology, Medicine
  • Nature
  • Many late-onset neurodegenerative diseases, including Parkinson's disease and Huntington's disease, are associated with the formation of intracellular aggregates by toxic proteins. It is therefore crucial to understand the factors that regulate the steady-state levels of these 'toxins', at both the synthetic and degradation stages. The degradation pathways acting on such aggregate-prone cytosolic proteins include the ubiquitin–proteasome system and macroautophagy. Dysfunction of the ubiquitin… CONTINUE READING
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