The roles of integration in molecular systems biology.

@article{OMalley2012TheRO,
  title={The roles of integration in molecular systems biology.},
  author={Maureen A. O’Malley and Orkun S. Soyer},
  journal={Studies in history and philosophy of biological and biomedical sciences},
  year={2012},
  volume={43 1},
  pages={
          58-68
        }
}

Explanation in Systems Biology: Is It All About Mechanisms?

It is argued that a purely mechanism-based framework that complies with the constraints stipulated by the new mechanists is adequate for producing useful explanations of biological phenomena in the context of the systems approach, and it is proposed that philosophers do not need to make a choice between adopting either a theoretical or a pragmatic attitude.

Contextualizing Systems Biology

A broad analysis of this new approach to systems biology was undertaken from the social and cultural studies of science perspective, the results of which are laid down in this book.

When one model is not enough: combining epistemic tools in systems biology.

  • Sara Green
  • Philosophy
    Studies in history and philosophy of biological and biomedical sciences
  • 2013

Systems Biology and Education

This chapter focuses on what challenges and opportunities the massive use of formal models has brought to biology and how systems biology has already started to challenge some of the standard views about the status of biology as a science.

Evolutionary systems biology: historical and philosophical perspectives on an emerging synthesis.

This chapter will outline the varieties of ESB existing today by tracing the diverse roots and fusions that make up this integrative project, and examines some strong general claims about ESB, particularly that it can be viewed as the next step toward a fuller modern synthesis of evolutionary biology (EB).

Integration in biology: Philosophical perspectives on the dynamics of interdisciplinarity.

  • Ingo Brigandt
  • Psychology
    Studies in history and philosophy of biological and biomedical sciences
  • 2013

Introduction: the plurality of modeling

A focus on the use of models, rather than on their content, shows that the distinction between biological and medical models is theoretically sound, and some interesting forms of explanation come to the fore.

Introduction: the plurality of modeling

A focus on the use of models, rather than on their content, shows that the distinction between biological and medical models is theoretically sound, and some interesting forms of explanation come to the fore.

Systems science and the art of interdisciplinary integration

This chapter outlines how some of the challenges play out in systems biology where disciplinary ideals and domain specific practices sometime collide and proposes that addressing and explicating the disciplinary background for the different views can help facilitate interdisciplinary collaboration in science as well as serve to improve science education.

Integration of approaches in David Wake's model-taxon research platform for evolutionary morphology.

  • J. Griesemer
  • Computer Science
    Studies in history and philosophy of biological and biomedical sciences
  • 2013
...

References

SHOWING 1-10 OF 140 REFERENCES

Beyond Reduction and Pluralism: Toward an Epistemology of Explanatory Integration in Biology

It is argued that the particular combination of disciplines and theoretical approaches needed to address a complex biological problem and which among them is explanatorily more fundamental varies with the problem pursued, as solving a complex problem need not require theoretical unification or the stable synthesis of different biological fields.

The methodologies of systems biology

Integrating sciences by creating new disciplines: The case of cell biology

It is argued that the embodiment of theories in scientists, and the institutions in which scientists work and the instruments they employ, are critical to the sort of integration that actually occurs in science.

Genomic Biology

Experimental Complexity in Biology: Some Epistemological and Historical Remarks

The argument is that the complexity of the research object is epistemically retained in the rich context of an experimental landscape, where the eruption of "volcanic systems" can change the scenery dramatically as the result of particular, unprecedented findings.

Philosophy of experimental biology

Philosophy of Experimental Biology concludes that historical explanations of scientific change that are based on local laboratory practice need to be supplemented with an account of the epistemic norms and standards that are operative in science.

Synthetic Biology and the Emergence of a Dual Meaning of Noise

The question is discussed how noise gained a functional meaning in the context of biology. According to the common view, noise is considered a disturbance or perturbation. I analyze how this

Systems biology, proteomics, and the future of health care: toward predictive, preventative, and personalized medicine.

In this review, systems biology is defined, the current capabilities of proteomics are discussed and some of the necessary milestones for moving systems biology and proteomics into mainstream health care are highlighted.

The nature of systems biology.

Conceptualizing the (Dis)unity of Science*

This paper argues that conceptualizing unity as “interconnection” (rather than reduction) provides a more fruitful and versatile framework for the philosophical study of scientific unification.
...