The roles of hypoxia in the in vitro engineering of tissues.

  title={The roles of hypoxia in the in vitro engineering of tissues.},
  author={Jos Malda and Travis Jacob Klein and Zee Upton},
  journal={Tissue engineering},
  volume={13 9},
Oxygen is a potent modulator of cell function and wound repair in vivo. The lack of oxygen (hypoxia) can create a potentially lethal environment and limit cellular respiration and growth or, alternatively, enhance the production of the specific extracellular matrix components and increase angiogenesis through the hypoxia-inducible factor-1 pathway. For the in vitro generation of clinically relevant tissue-engineered grafts, these divergent actions of hypoxia should be addressed. Diffusion… CONTINUE READING


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