The roles of hemagglutinin Phe-95 in receptor binding and pathogenicity of influenza B virus.

@article{Ni2014TheRO,
  title={The roles of hemagglutinin Phe-95 in receptor binding and pathogenicity of influenza B virus.},
  author={Fengyun Ni and Innocent Nnadi Mbawuike and Elena Kondrashkina and Qinghua Wang},
  journal={Virology},
  year={2014},
  volume={450-451},
  pages={
          71-83
        }
}
Diverged ~4000 years ago, influenza B virus has several important differences from influenza A virus, including lower receptor-binding affinity and highly restricted host range. Based on our prior structural studies, we hypothesized that a single-residue difference in the receptor-binding site of hemagglutinin (HA), Phe-95 in influenza B virus versus Tyr-98 in influenza A/H1-H15, is possibly a key determinant for the low receptor-binding affinity. Here we demonstrate that the mutation Phe95→Tyr… CONTINUE READING