• Biology
  • Published 2009

The roles of chemokines on rabies virus pathogenicity and immunogenicity

@inproceedings{Zhao2009TheRO,
  title={The roles of chemokines on rabies virus pathogenicity and immunogenicity},
  author={Ling Zhao},
  year={2009}
}
It has been found previously that induction of innate immunity, particularly chemokines, is an important mechanism of rabies virus (RABV) attenuation. To evaluate the effect of overexpression of chemokines on RABV infection, chemokines MIP-1α, RANTES and IP-10 were individually cloned into the genome of attenuated RABV strain HEP-Flury. These recombinant RABVs were characterized in vitro for growth properties and expression of chemokines. It was found that all the recombinant viruses grow as… CONTINUE READING

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