The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis.

@article{Jilling2006TheRO,
  title={The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis.},
  author={Tamas Jilling and Dyan M. Simon and Jing Hua Lu and Fan Jing Meng and Dan Li and Robert Schy and Richard B. Thomson and Antoine Soliman and Moshe Arditi and Michael S. Caplan},
  journal={Journal of immunology},
  year={2006},
  volume={177 5},
  pages={3273-82}
}
Bacteria are thought to contribute to the pathogenesis of necrotizing enterocolitis (NEC), but it is unknown whether their interaction with the epithelium can participate in the initiation of mucosal injury or they can act only following translocation across a damaged intestinal barrier. Our aims were to determine whether bacteria and intestinal epithelial TLR4 play roles in a well-established neonatal rat model and a novel neonatal murine model of NEC. Neonatal rats, C57BL/6J, C3HeB/FeJ (TLR4… CONTINUE READING
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