The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions.

@article{Heinlein2002TheRO,
  title={The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions.},
  author={Cynthia A. Heinlein and Chawnshang Chang},
  journal={Molecular endocrinology},
  year={2002},
  volume={16 10},
  pages={
          2181-7
        }
}
The biological activity of testosterone and dihydrotestosterone is thought to occur predominantly through binding to the androgen receptor (AR), a member of the nuclear receptor superfamily that functions as a ligand-activated transcription factor. However, androgens have also been reported to induce the rapid activation of kinase-signaling cascades and modulate intracellular calcium levels. These effects are considered to be nongenomic because they occur in cell types that lack a functional AR… CONTINUE READING

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