The roles of amino acid residues at positions 216 and 219 in the structural stability and metabolic functions of rat cytochrome P450 2D1 and 2D2.

Abstract

We examined the effects of the mutual substitution of amino acid residues at positions 216 and 219 between rat CYP2D1 and CYP2D2 on their microsomal contents and enzymatic functions using a yeast cell expression system and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) as a substrate. CYP2D1 has amino acid residues, leucine and valine, at positions of 216… (More)
DOI: 10.1016/j.cbi.2007.11.010

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Cite this paper

@article{Narimatsu2008TheRO, title={The roles of amino acid residues at positions 216 and 219 in the structural stability and metabolic functions of rat cytochrome P450 2D1 and 2D2.}, author={Shizuo Narimatsu and Kimio Kiryu and Rei Yonemoto and Manabu Yoshino and Mitsuko Kobatake and Daichi Kazamori and Saori Hagino and Kazufumi Masuda and Takashi Katsu and Masato Asanuma and Takuya Kumamoto and Tsutomu Ishikawa and Yoshihiko Funae and Shigeru Yamano and Nobumitsu Hanioka and Shinsaku Naito}, journal={Chemico-biological interactions}, year={2008}, volume={172 1}, pages={11-21} }