The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation.

@article{Cho2003TheRO,
  title={The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation.},
  author={Moon Jun Cho and Jun-ling Liu and Tamara I. Pestina and Shirley A. Steward and Dennis W. Thomas and Thomas M. Coffman and Demin Wang and Carl Jackson and Theodore Kent Gartner},
  journal={Blood},
  year={2003},
  volume={101 7},
  pages={2646-51}
}
Collagen-induced activation of platelets in suspension leads to alpha(IIb)beta(3)-mediated outside-in signaling, granule release, thromboxane A2 (TxA2) production, and aggregation. Although much is known about collagen-induced platelet signaling, the roles of TxA2 production, adenosine diphosphate (ADP) and dense-granule secretion, and alpha(IIb)beta(3)-mediated outside-in signaling in this process are unclear. Here, we demonstrate that TxA2 and ADP are required for collagen-induced platelet… CONTINUE READING

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