The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey

@article{Knobbe2008TheRO,
  title={The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey},
  author={Christiane B. Knobbe and Valentina Lapin and A Suzuki and Tak W. Mak},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={5398-5415}
}
In 1997, PTEN (phosphatase and tensin homologue deleted on chromosome 10, 10q23.3) was identified as an important tumor suppressor gene that is inactivated in a wide variety of human cancers. Ever since, PTEN's function has been extensively studied, and huge progress has been made in understanding PTEN's role in normal physiology and disease. In this review, we will systematically summarize the important data that have been gained from gene inactivation studies in mice and will put these data… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 60 CITATIONS, ESTIMATED 48% COVERAGE

PTEN signaling through RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK in the epididymis is essential for male fertility.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2014
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

PTEN-opathies: from biological insights to evidence-based precision medicine.

  • The Journal of clinical investigation
  • 2019
VIEW 3 EXCERPTS
CITES BACKGROUND

FILTER CITATIONS BY YEAR

2009
2019

CITATION STATISTICS

  • 3 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 103 REFERENCES

Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas.

  • The Journal of clinical investigation
  • 2004
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

PTEN function

S Backman, V Stambolic, T. Mak
  • 2002
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL