The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey

@article{Knobbe2008TheRO,
  title={The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey},
  author={C. Knobbe and V. Lapin and A. Suzuki and T. Mak},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={5398-5415}
}
In 1997, PTEN (phosphatase and tensin homologue deleted on chromosome 10, 10q23.3) was identified as an important tumor suppressor gene that is inactivated in a wide variety of human cancers. Ever since, PTEN's function has been extensively studied, and huge progress has been made in understanding PTEN's role in normal physiology and disease. In this review, we will systematically summarize the important data that have been gained from gene inactivation studies in mice and will put these data… Expand
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  • Biology, Medicine
  • Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • 2008
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TLDR
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Hypermethylation of FOXA1 and allelic loss of PTEN drive squamous differentiation and promote heterogeneity in bladder cancer
TLDR
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TLDR
Results reveal the effects of combined p53- and PTEN-deficiency on MEOX1 expression and TNBC cell proliferation, suggesting that MEOx1 may serve as a potential therapeutic target for managing p53/p53/ PTENdeficient TNBC. Expand
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