The roles of Jumonji-type oxygenases in human disease

  title={The roles of Jumonji-type oxygenases in human disease},
  author={Catrine Johansson and Anthony Tumber and KaHing Che and Peter Cain and Radoslaw P. Nowak and Carina Gileadi and Udo C. T. Oppermann},
The iron- and 2-oxoglutarate-dependent oxygenases constitute a phylogenetically conserved class of enzymes that catalyze hydroxylation reactions in humans by acting on various types of substrates, including metabolic intermediates, amino acid residues in different proteins and various types of nucleic acids. The discovery of jumonji (Jmj), the founding member of a class of Jmj-type chromatin modifying enzymes and transcriptional regulators, has culminated in the discovery of several branches of… CONTINUE READING
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