The roles of CYP2D6 and stereoselectivity in the clinical pharmacokinetics of chlorpheniramine.

@article{Yasuda2002TheRO,
  title={The roles of CYP2D6 and stereoselectivity in the clinical pharmacokinetics of chlorpheniramine.},
  author={S. Yasuda and P. Zannikos and Andrea E Young and K. Fried and I. Wainer and R. Woosley},
  journal={British journal of clinical pharmacology},
  year={2002},
  volume={53 5},
  pages={
          519-25
        }
}
AIMS To examine the stereoselective disposition of chlorpheniramine and to evaluate the role of CYP2D6 in chlorpheniramine pharmacokinetics in humans. METHODS Eight healthy volunteers (six extensive metabolizers with respect to CYP2D6 and two poor metabolizers) received a single 8 mg oral dose of rac-chlorpheniramine either given alone or following administration of quinidine 50 mg every 6 h for 2 days prior to the study day and every 6 h thereafter until the end of the study. Plasma… Expand
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